|Other Names||Ribosomal protein S6 kinase beta-2, S6K-beta-2, S6K2, 70 kDa ribosomal protein S6 kinase 2, P70S6K2, p70-S6K 2, S6 kinase-related kinase, SRK, Serine/threonine-protein kinase 14B, p70 ribosomal S6 kinase beta, S6K-beta, p70 S6 kinase beta, p70 S6K-beta, p70 S6KB, p70-beta, RPS6KB2, STK14B|
|Target/Specificity||The synthetic peptide sequence is selected from aa 5-19 of HUMAN RPS6KB2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates specifically ribosomal protein S6.|
|Cellular Location||Cytoplasm. Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
Raught, B., et al., EMBO J. 23(8):1761-1769 (2004).
Lekmine, F., et al., Exp. Cell Res. 295(1):173-182 (2004).
Shao, J., et al., Cancer Res. 64(1):229-235 (2004).
An, W.L., et al., Am. J. Pathol. 163(2):591-607 (2003).
Levy, Y., et al., J. Biol. Chem. 278(16):14533-14542 (2003).
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