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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PIK3R1 Antibody (Y528) Blocking Peptide   

PIK3R1 Antibody (Y528) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P27986
Clone Names 109223
Peptide ID 109223
Additional Information
Gene ID 5295
Other Names Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha, PIK3R1, GRB1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8023c was selected from the Y528 region of human PIK3R1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIK3R1
Synonyms GRB1
Function Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Tissue Location Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level)
Research Areas
Citations (0)

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Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance.


Kobayashi, H., et al., J. Biol. Chem. 279(8):6371-6379 (2004).Liu, H., et al., J. Cell Biol. 164(4):603-612 (2004).Sun, M., et al., J. Biol. Chem. 278(44):42992-43000 (2003).Khan, N.A., et al., J. Neurovirol. 9(6):584-593 (2003).Lee, H.Y., et al., J. Biol. Chem. 278(26):23630-23638 (2003).

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$ 80.00
Cat# BP8023c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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