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PI4KCB Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UBF8
Other Accession Q5VWB9
Clone Names 2070810
Additional Information
Gene ID 5298
Other Names Phosphatidylinositol 4-kinase beta, PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta, NPIK, PI4K92, PI4KB, PIK4CB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8030b was selected from the C-term region of human PI4KCB . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PI4KB
Synonyms PIK4CB
Function Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).
Cellular Location Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex
Tissue Location Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver.
Research Areas
Citations (0)

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Phosphoinositides are pivotal precursors to important second messengers and as signaling and molecules. Phosphatidylinositol 4-kinases (PI4Ks) are are crucial regulators of the phosphoinsitide cascade. PI4KCB is a wortmannin-sensitive PI 4-kinase responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides. The cellular reservoir of PI4KCB is predominantly cytosolic, however the protein is is activated strongly by recruitment to the membrane to stimulate phosphatidylinositol 4,5-bisphosphate synthesis at the plasma membrane. PI4KCB contains an N-terminal lipid kinase unique domain, which is shared by members of both the PI3 kinase and PI4 kinase families, and a C-terminal catalytic domain, which defines this protein as a member of a much larger protein/lipid kinase family.


Wei, Y.J., et al., J. Biol. Chem. 277(48):46586-46593 (2002).Balla, A., et al., J. Biol. Chem. 277(22):20041-20050 (2002).Sorensen, S.D., et al., Mol. Pharmacol. 53(5):827-836 (1998).Saito, T., et al., DNA Res. 4(4):301-305 (1997).Suzuki, K., et al., DNA Res. 4(4):273-280 (1997).

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$ 80.00
Cat# BP8030b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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