|Other Names||Guanine nucleotide-binding protein subunit alpha-12, G alpha-12, G-protein subunit alpha-12, GNA12|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8035a was selected from the S67 region of human GNA12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade.|
|Cellular Location||Membrane; Lipid-anchor.|
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Provided below are standard protocols that you may find useful for product applications.
Guanine nucleotide-binding proteins (G proteins) are modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 subunits; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Krakstad, B.F., et al., Proc. Natl. Acad. Sci. U.S.A. 101(28):10314-10319 (2004).Hillier, L.W., et al., Nature 424(6945):157-164 (2003).Scherer, S.W., et al., Science 300(5620):767-772 (2003).Suzuki, N., et al., Proc. Natl. Acad. Sci. U.S.A. 100(2):733-738 (2003).Yamaguchi, Y., et al., J. Biol. Chem. 278(17):14936-14939 (2003).
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