|Other Names||Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta, Diphosphoinositide kinase 2-beta, Phosphatidylinositol 5-phosphate 4-kinase type II beta, PI(5)P 4-kinase type II beta, PIP4KII-beta, PtdIns(5)P-4-kinase isoform 2-beta, PIP4K2B, PIP5K2B|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8042a was selected from the N-term region of human PIP5K2B . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein Nucleus. Cytoplasm. Note=Associated with the plasma membrane and the endoplasmic reticulum.|
|Tissue Location||Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.|
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Provided below are standard protocols that you may find useful for product applications.
PIP5K2B catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. It is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.
Rao, V.D., et al., Cell 94(6):829-839 (1998).Castellino, A.M., et al., J. Biol. Chem. 272(9):5861-5870 (1997).
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