BRD1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95696 |
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Clone Names | 3022409 |
Gene ID | 23774 |
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Other Names | Bromodomain-containing protein 1, BR140-like protein, Bromodomain and PHD finger-containing protein 2, BRD1, BRL, BRPF2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8048b was selected from the C-term region of human BRD1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | BRD1 {ECO:0000303|PubMed:16387653, ECO:0000312|HGNC:HGNC:1102} |
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Function | Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). |
Cellular Location | Nucleus. Chromosome Note=Localizes to transcription start sites |
Tissue Location | Highly expressed in testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.
References
McCullagh, P., et al., Oncogene 18(52):7442-7452 (1999).Dunham, I., et al., Nature 402(6761):489-495 (1999).Haynes, S.R., et al., Nucleic Acids Res. 20 (10), 2603 (1992).
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