|Other Names||Bromodomain-containing protein 2, O2711, Really interesting new gene 3 protein, BRD2, KIAA9001, RING3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8049c was selected from the Center region of human BRD2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.|
|Cellular Location||Nucleus. Note=Detected on chromatin and nucleosomes|
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Provided below are standard protocols that you may find useful for product applications.
BRD2 is a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human protein may be part of a signal transduction pathway involved in growth control.
Pal, D.K., et al., Am. J. Hum. Genet. 73(2):261-270 (2003).Crowley, T.E., et al., Mol. Endocrinol. 16(8):1727-1737 (2002).Denis, G.V., et al., Cell Growth Differ. 11(8):417-424 (2000).Taniguchi, Y., et al., Genomics 51(1):114-123 (1998).Thorpe, K.L., et al., Immunogenetics 44(5):391-396 (1996).
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