|Other Names||Bromodomain-containing protein 3, RING3-like protein, BRD3, KIAA0043, RING3L|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8050b was selected from the C-term region of human BRD3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.|
|Cellular Location||Nucleus. Note=Detected on chromatin.|
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Provided below are standard protocols that you may find useful for product applications.
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known.
Kaneko, H., et al., J Investig Allergol Clin Immunol 12(2):86-90 (2002).Thorpe, K.L., et al., Immunogenetics 44(5):391-396 (1996).Thorpe, K.L., et al., Gene 200 (1-2), 177-183 (1997).
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