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DGKZ Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q13574
Clone Names 3041110
Additional Information
Gene ID 8525
Other Names Diacylglycerol kinase zeta, DAG kinase zeta, Diglyceride kinase zeta, DGK-zeta, DGKZ, DAGK6
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8060b was selected from the C-term region of human DGKZ . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DGKZ (HGNC:2857)
Synonyms DAGK6
Function Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity).
Cellular Location Nucleus. Cytoplasm, cytosol. Cell membrane. Cell projection, lamellipodium
Tissue Location Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas.
Research Areas
Citations (0)
citation

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Background

DGKZ belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellularsignaling cascade and signal transduction.

References

Hogan, A., et al., J. Biol. Chem. 276(28):26526-26533 (2001).Topham, M.K., et al., Nature 394(6694):697-700 (1998).Ding, L., et al., Proc. Natl. Acad. Sci. U.S.A. 94(11):5519-5524 (1997).Bunting, M., et al., J. Biol. Chem. 271(17):10230-10236 (1996).

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$ 277.78
Cat# BP8060b
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