|Other Names||Proto-oncogene serine/threonine-protein kinase mos, Oocyte maturation factor mos, Proto-oncogene c-Mos, MOS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8069b was selected from the C-term region of human MOS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed specifically in testis during spermatogenesis|
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Mos, the c-mos protooncogene product, is a key regulator of meiosis in vertebrates. MOS is a 39kDa proto oncogene (c-Mos) encoded protein serine/threonine kinase. MOS is a monomeric protein that indirectly activates MAP kinase (Erk1/2) by directly phosphorylating MAP kinase kinase (Mck, MAPKK, MKK). MOS is known as a cytostatic factor (CSF) and is also thought to arrest unfertilized amphibian and mammalian cells during M phase, thus regulating oocyte maturation. MOS is destroyed before fertilisation, after exit from meiosis II, making it a good marker for studies of eggs during oogenesis and maturation.
Caubet, J.F., et al., EMBO J. 4(9):2245-2248 (1985).Watson, R., et al., Proc. Natl. Acad. Sci. U.S.A. 79(13):4078-4082 (1982).Singh, B., et al., Prog Cell Cycle Res 3, 251-259 (1997).
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