|Other Names||Nucleoside diphosphate kinase 6, NDK 6, NDP kinase 6, Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha, nm23-H6, NME6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8083a was selected from the N-term region of human NME6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.|
|Tissue Location||Expressed at a moderately low level in many tissues. Most abundant in kidney, prostate, ovary, intestine, and spleen|
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Provided below are standard protocols that you may find useful for product applications.
NME6 plays a major role in the synthesis of nucleoside triphosphates other than ATP. It is an inhibitor of p53-induced apoptosis. NME6 is expressed at a moderately low level in many tissues, most abundantly in kidney, prostate, ovary, intestine, and spleen.
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Mehus, J.G., et al., Hum. Genet. 104(6):454-459 (1999).
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