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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PKA R2 (PKR2) Antibody (N-term) Blocking peptide   

PKA R2 (PKR2) Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P13861
Other Accession KAP2_HUMAN
Clone Names 3011706
Peptide ID 3011706
Additional Information
Gene ID 5576
Other Names cAMP-dependent protein kinase type II-alpha regulatory subunit, PRKAR2A, PKR2, PRKAR2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8096a was selected from the N-term region of human PKR2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRKAR2A
Synonyms PKR2, PRKAR2
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Cellular Location Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and the cell membrane
Tissue Location Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible
Research Areas
Citations (0)

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Background

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. PKR2 is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of AMPK. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

References

MacDougall, M.W., et al., J. Clin. Endocrinol. Metab. 88(5):2194-2205 (2003).Birkeli, K.A., et al., J. Biol. Chem. 278(3):1991-1997 (2003).Sun, F., et al., J. Biol. Chem. 275(19):14360-14366 (2000).Zakhary, D.R., et al., J. Biol. Chem. 275(52):41389-41395 (2000).Tasken, K., et al., Genomics 50(3):378-381 (1998).

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$ 80.00
Cat# BP8096a
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