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WEE1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P30291
Clone Names 3031405
Additional Information
Gene ID 7465
Other Names Wee1-like protein kinase, WEE1hu, Wee1A kinase, WEE1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8106b was selected from the C-term region of human WEE1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WEE1
Function Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Cellular Location Nucleus.
Research Areas
Citations (0)
citation

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Background

WEE1 is a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.

References

Kawasaki, H., et al., Oncogene 22(44):6839-6844 (2003).Hashimoto, O., et al., Mol. Carcinog. 36(4):171-182 (2003).Yuan, H., et al., J. Virol. 77(3):2063-2070 (2003).Masaki, T., et al., Hepatology 37(3):534-543 (2003).de Noronha, C.M., et al., Science 294(5544):1105-1108 (2001).

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$ 277.78
Cat# BP8106b
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Availability: 2 weeks
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