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WNK1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9H4A3
Clone Names 3011709
Additional Information
Gene ID 65125
Other Names Serine/threonine-protein kinase WNK1, Erythrocyte 65 kDa protein, p65, Kinase deficient protein, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, hWNK1, WNK1, HSN2, KDP, KIAA0344, PRKWNK1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8107b was selected from the C-term region of human WNK1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WNK1
Synonyms HSN2, KDP, KIAA0344, PRKWNK1
Function Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L.
Cellular Location Cytoplasm.
Tissue Location Widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Isoform 3 is kidney-specific and specifically expressed in the distal convoluted tubule (DCT) and connecting tubule (CNT) of the nephron.
Research Areas
Citations (0)

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The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron.[supplied by OMIM]


Xu, B.E., et al., J. Biol. Chem. 277(50):48456-48462 (2002).Verissimo, F., et al., Oncogene 20(39):5562-5569 (2001).Wilson, F.H., et al., Science 293(5532):1107-1112 (2001).Moore, T.M., et al., J. Biol. Chem. 275(6):4311-4322 (2000).

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$ 80.00
Cat# BP8107b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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