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|Other Names||Atrial natriuretic peptide receptor 2, Atrial natriuretic peptide receptor type B, ANP-B, ANPR-B, NPR-B, Guanylate cyclase B, GC-B, NPR2, ANPRB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8112a was selected from the N-term region of human ANPB . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
Provided below are standard protocols that you may find useful for product applications.
ANPB (natriuretic peptide receptor B) is one of two integral membrane receptors for natriuretic peptides. Both ANPA and ANPB contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain), an helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. ANPB is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity.
van den Akker, F., J. Mol. Biol. 311(5):923-937 (2001).Hirsch, J.R., et al., J. Am. Soc. Nephrol. 10(3):472-480 (1999).Rehemudula, D., et al., Circ. Res. 84(5):605-610 (1999).Potter, L.R., et al., J. Biol. Chem. 273(25):15533-15539 (1998).Duda, T., et al., Biochemistry 32(6):1391-1395 (1993).
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