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DGKE Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P52429
Clone Names 3050303
Peptide ID 3050303
Additional Information
Gene ID 8526
Other Names Diacylglycerol kinase epsilon, DAG kinase epsilon, Diglyceride kinase epsilon, DGK-epsilon, DGKE, DAGK5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8125a was selected from the N-term region of human DGKE . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DGKE
Synonyms DAGK5
Function Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
Cellular Location Membrane; Multi-pass membrane protein. Membrane Cytoplasm
Tissue Location Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level)
Research Areas
Citations (0)

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Background

Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGKE shows specificity for arachidonyl-containing diacylglycerol. DGKE is expressed predominantly in testis.

References

Tang, W., et al., Gene 239(1):185-192 (1999).Hart, T.C., et al., Genomics 56(2):233-235 (1999).Tang, W., et al., J. Biol. Chem. 271(17):10237-10241 (1996).

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$ 80.00
Cat# BP8125a
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