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HK1 (Hexokinase) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P19367
Other Accession NP_277032
Clone Names 4011423
Peptide ID 4011423
Additional Information
Gene ID 3098
Other Names Hexokinase-1, Brain form hexokinase, Hexokinase type I, HK I, HK1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8141d was selected from the N-term region of human HK1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HK1
Cellular Location Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding
Tissue Location Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific
Research Areas
Citations (0)

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Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.


van Wijk, R., et al., Blood 101(1):345-347 (2003).Murakami, K., et al., Acta Haematol. 108(4):204-209 (2002).Murakami, K., et al., Mol. Genet. Metab. 67(2):118-130 (1999).Aleshin, A.E., et al., Structure 6(1):39-50 (1998).Ruzzo, A., et al., Blood 91(1):363-364 (1998).

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$ 80.00
Cat# BP8141d
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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