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FGF4 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P08620
Clone Names 3052810
Additional Information
Gene ID 2249
Other Names Fibroblast growth factor 4, FGF-4, Heparin secretory-transforming protein 1, HST, HST-1, HSTF-1, Heparin-binding growth factor 4, HBGF-4, Transforming protein KS3, FGF4, HST, HSTF1, KS3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8149a was selected from the N-term region of human FGF4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGF4
Synonyms HST, HSTF1, KS3
Function Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

FGF4 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The gene for FGF4 was identified by its oncogenic transforming activity. The gene for FGF4 and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

References

Yamamoto, H., et al., Oncogene 21(6):899-908 (2002).Koh, K.R., et al., Leuk. Res. 26(10):933-938 (2002).Sieuwerts, A.M., et al., Thromb. Haemost. 87(4):674-683 (2002).Lopez-Sanchez, C., et al., Cell Tissue Res. 309(2):237-249 (2002).Galland, F., et al., Cytogenet. Cell Genet. 60(2):114-116 (1992).

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$ 80.00
Cat# BP8149a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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