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YWHAB Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P31946
Clone Names 3060205
Additional Information
Gene ID 7529
Other Names 14-3-3 protein beta/alpha, Protein 1054, Protein kinase C inhibitor protein 1, KCIP-1, 14-3-3 protein beta/alpha, N-terminally processed, YWHAB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8155a was selected from the 14-3-3 region of human YWHAB (14-3-3 protein beta/alpha) . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name YWHAB
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Cellular Location Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
Citations (0)
citation

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Background

YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.

References

Komori, T., et al., Acta Neuropathol. 106(1):66-70 (2003).Cavet, M.E., et al., J. Biol. Chem. 278(20):18376-18383 (2003).Li, Y., et al., J. Biol. Chem. 278(16):13663-13671 (2003).Shumway, S.D., et al., J. Biol. Chem. 278(4):2089-2092 (2003).Parvaresch, S., et al., FEBS Lett. 532(3):357-362 (2002).

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$ 277.78
Cat# BP8155a
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