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PLAUR Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q03405
Clone Names 3060208
Additional Information
Gene ID 5329
Other Names Urokinase plasminogen activator surface receptor, U-PAR, uPAR, Monocyte activation antigen Mo3, CD87, PLAUR, MO3, UPAR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8156b was selected from the C-term region of human PLAUR . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MO3, UPAR
Function Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Cellular Location Cell membrane. Cell projection, invadopodium membrane. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner Isoform 2: Secreted {ECO:0000250|UniProtKB:P49616}
Tissue Location Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain
Research Areas
Citations (0)

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The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion.1 It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins.2 PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue.3 Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer.4 UPAR appears to be a useful prognostic marker for advanced endometrial cancer.


Borgfeldt, C., et al., Int. J. Cancer 107(4):658-665 (2003).Tran, H., et al., Mol. Cell. Biol. 23(20):7177-7188 (2003).Coleman, J.L., et al., Infect. Immun. 71(10):5556-5564 (2003).Sturge, J., et al., J. Cell Biol. 162(5):789-794 (2003).Li, Y., et al., J. Biol. Chem. 278(32):29925-29932 (2003).

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$ 80.00
Cat# BP8156b
Availability: In Stock
Bulk Size
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