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Urokinase (PLAU) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P00749
Clone Names 3060406
Peptide ID 3060406
Additional Information
Gene ID 5328
Other Names Urokinase-type plasminogen activator, U-plasminogen activator, uPA, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B, PLAU
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8161a was selected from the N-term region of human PLAU . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Cellular Location Secreted.
Tissue Location Expressed in the prostate gland and prostate cancers.
Research Areas
Citations (0)

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PLAU, a member of the peptidase family S1, is a potent plasminogen activator and is clinically used for therapy of thrombolytic disorders. PLAU specifically cleaves the Arg-|-Val bond in plasminogen to form plasmin. The protein is found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A. Cleavage occurs after residue 155 in the low molecular mass form to yield a short A1 chain. The protein is used in Pulmonary Embolism (PE) to initiates fibrinolysis. Structurally, PLAU contains 1 EGF-like domain and 1 kringle domain.


Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Sperl, S., et al., Proc. Natl. Acad. Sci. U.S.A. 97(10):5113-5118 (2000).Turkmen, B., et al., Electrophoresis 18(5):686-689 (1997).Conne, B., et al., Thromb. Haemost. 77(3):434-435 (1997).Yoshimoto, M., et al., Biochim. Biophys. Acta 1293(1):83-89 (1996).

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$ 80.00
Cat# BP8161a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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