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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   EEF2K Antibody (N-term) Blocking Peptide   

EEF2K Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O00418
Other Accession NP_037434
Clone Names 4011205
Peptide ID 4011205
Additional Information
Gene ID 101930123;29904
Other Names Eukaryotic elongation factor 2 kinase, eEF-2 kinase, eEF-2K, Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase, EEF2K
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8162a was selected from the N-term region of human EEF2K. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EEF2K
Function Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Research Areas
Citations (0)

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Eukaryotic elongation factor 2 kinase (eEF2k) phosphorylates and inactivates eEF2, thereby inhibiting peptide-chain elongation. eEF2k, which is Ca2+ and calmodulin dependent, can be activated by PKA in response to stress-induced elevation of cAMP levels. eEF2k expression is also modulated by a wide range of stimuli that promote cell growth and protein synthesis. Phosphorylation of eEF2k by p90RSK and p70 S6 kinase at Ser366 or by SAPK4/p38d at Ser359, inactivates eEF2k, which facilitates the dephosphorylation of eEF2, and thus promotes translation.


Mol. Cell. Biol. 24 (7), 2986-2997 (2004)J. Biol. Chem. 279 (13), 12220-12231 (2004)Biochem. J. 367 (PT 2), 525-532 (2002)EMBO J. 20 (16), 4370-4379 (2001)

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$ 80.00
Cat# BP8162a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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