|Other Names||L-fucose kinase, Fucokinase, FUK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8165b was selected from the C-term region of human Fucokinase. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.|
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Provided below are standard protocols that you may find useful for product applications.
Fucokinase belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis.
Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Hinderlich, S., et al., Biochem. Biophys. Res. Commun. 294(3):650-654 (2002).
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