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ITPKA Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P23677
Other Accession NP_002211
Clone Names 4011605
Additional Information
Gene ID 3706
Other Names Inositol-trisphosphate 3-kinase A, Inositol 1, 5-trisphosphate 3-kinase A, IP3 3-kinase A, IP3K A, InsP 3-kinase A, ITPKA
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8166a was selected from the N-term region of human ITPKA . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITPKA (HGNC:6178)
Function Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5- trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.
Cellular Location Cytoplasm, cytoskeleton
Tissue Location Expressed in brain..
Research Areas
Citations (0)
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Background

ITPKA regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region.

References

Gonzalez, B., et al., Mol. Cell 15(5):689-701 (2004).Mishra, J., et al., Biophys. J. 83(3):1298-1316 (2002).Schell, M.J., et al., J. Biol. Chem. 276(40):37537-37546 (2001).Communi, D., et al., EMBO J. 16(8):1943-1952 (1997).Woodring, P.J., et al., J. Biol. Chem. 272(48):30447-30454 (1997).

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$ 277.78
Cat# BP8166a
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Availability: 2 weeks
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