|Other Names||Mevalonate kinase, MK, MVK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8169a was selected from the N-term region of human MVK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be a regulatory site in cholesterol biosynthetic pathway.|
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Provided below are standard protocols that you may find useful for product applications.
MVK encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of MVK results in mevalonic aciduria.
Stojanov, S., et al., Arthritis Rheum. 50(6):1951-1958 (2004).Nair, A.K., et al., J. Biol. Chem. 279(15):14937-14944 (2004).Simon, A., et al., Neurology 62(6):994-997 (2004).Houten, S.M., et al., J. Biol. Chem. 278(8):5736-5743 (2003).Houten, S.M., et al., Eur. J. Hum. Genet. 11(2):196-200 (2003).
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