MVP Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q03426 |
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Other Accession | NP_000422 |
Clone Names | 4012107 |
Gene ID | 4598 |
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Other Names | Mevalonate kinase, MK, MVK |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8169b was selected from the C-term region of human MVP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MVK (HGNC:7530) |
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Function | Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:9325256, PubMed:18302342, PubMed:9392419, PubMed:11278915). |
Cellular Location | Cytoplasm. Peroxisome {ECO:0000250|UniProtKB:P17256} |
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Provided below are standard protocols that you may find useful for product applications.
Background
MVK encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of MVK results in mevalonic aciduria.
References
Stojanov, S., et al., Arthritis Rheum. 50(6):1951-1958 (2004).Nair, A.K., et al., J. Biol. Chem. 279(15):14937-14944 (2004).Simon, A., et al., Neurology 62(6):994-997 (2004).Houten, S.M., et al., J. Biol. Chem. 278(8):5736-5743 (2003).Houten, S.M., et al., Eur. J. Hum. Genet. 11(2):196-200 (2003).
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