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MVP Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q03426
Other Accession NP_000422
Clone Names 4012107
Additional Information
Gene ID 4598
Other Names Mevalonate kinase, MK, MVK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8169b was selected from the C-term region of human MVP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MVK (HGNC:7530)
Function Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:9325256, PubMed:18302342, PubMed:9392419, PubMed:11278915).
Cellular Location Cytoplasm. Peroxisome {ECO:0000250|UniProtKB:P17256}
Research Areas
Citations (0)
citation

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Background

MVK encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of MVK results in mevalonic aciduria.

References

Stojanov, S., et al., Arthritis Rheum. 50(6):1951-1958 (2004).Nair, A.K., et al., J. Biol. Chem. 279(15):14937-14944 (2004).Simon, A., et al., Neurology 62(6):994-997 (2004).Houten, S.M., et al., J. Biol. Chem. 278(8):5736-5743 (2003).Houten, S.M., et al., Eur. J. Hum. Genet. 11(2):196-200 (2003).

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$ 277.78
Cat# BP8169b
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