|Other Names||Brain-specific angiogenesis inhibitor 1, BAI1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8170a was selected from the C-term region of human BAI1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Likely to be concentrated at cell-cell adhesion sites|
|Tissue Location||Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes|
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Provided below are standard protocols that you may find useful for product applications.
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.
Kaur, B., et al., Am. J. Pathol. 162(1):19-27 (2003).Mori, K., et al., Neurosci. Res. 43(1):69-74 (2002).Duda, D.G., et al., Br. J. Cancer 86(3):490-496 (2002).Shiratsuchi, T., et al., Biochem. Biophys. Res. Commun. 247(3):597-604 (1998).Fukushima, Y., et al., Int. J. Oncol. 13(5):967-970 (1998).
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