|Other Names||Kinesin-1 heavy chain, Conventional kinesin heavy chain, Ubiquitous kinesin heavy chain, UKHC, KIF5B, KNS, KNS1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8170c was selected from the Central region of human Kif5B-1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.|
|Cellular Location||Cytoplasm, cytoskeleton. Note=Uniformly distributed between soma and neurites in hippocampal neurons.|
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Provided below are standard protocols that you may find useful for product applications.
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. It is composed of an oligomer consisting of two heavy chains and two light chains. Kinesin, which is thought to interact with GRIP1, possesses three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles. Kinesin is found in newborn and adult brain, liver, kidney, spleen, heart, lung and sciatic nerve.
Diefenbach, R.J., et al., Biochem. Biophys. Res. Commun. 319(3):987-992 (2004).Diefenbach, R.J., et al., Biochemistry 41(50):14906-14915 (2002).Hakimi, M.A., et al., J. Biol. Chem. 277(40):36909-36912 (2002).Tanaka, Y., et al., Cell 93(7):1147-1158 (1998).Rahman, A., et al., J. Biol. Chem. 273(25):15395-15403 (1998).
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