|Other Names||Receptor-type tyrosine-protein phosphatase F, Leukocyte common antigen related, LAR, PTPRF, LAR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8405a was selected from the C-term region of human LAR . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
LAR is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
Blanchetot, C., et al., J. Biol. Chem. 277(49):47263-47269 (2002).Tsujikawa, K., et al., Mol. Cancer Res. 1(2):155-163 (2002).Zabolotny, J.M., et al., Proc. Natl. Acad. Sci. U.S.A. 98(9):5187-5192 (2001).Muller, T., et al., J. Biol. Chem. 274(15):10173-10183 (1999).Ahmad, F., et al., J. Biol. Chem. 272(1):448-457 (1997).
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