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LAR Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P10586
Clone Names 1121704
Additional Information
Gene ID 5792
Other Names Receptor-type tyrosine-protein phosphatase F, Leukocyte common antigen related, LAR, PTPRF, LAR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8405a was selected from the C-term region of human LAR . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms LAR
Function Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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LAR is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.


Blanchetot, C., et al., J. Biol. Chem. 277(49):47263-47269 (2002).Tsujikawa, K., et al., Mol. Cancer Res. 1(2):155-163 (2002).Zabolotny, J.M., et al., Proc. Natl. Acad. Sci. U.S.A. 98(9):5187-5192 (2001).Muller, T., et al., J. Biol. Chem. 274(15):10173-10183 (1999).Ahmad, F., et al., J. Biol. Chem. 272(1):448-457 (1997).

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$ 80.00
Cat# BP8405a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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