PTP kappa Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q15262 |
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Clone Names | 1121008 |
Gene ID | 5796 |
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Other Names | Receptor-type tyrosine-protein phosphatase kappa, Protein-tyrosine phosphatase kappa, R-PTP-kappa, PTPRK, PTPK |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8417a was selected from the N-term region of human PTPkappa . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PTPRK |
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Synonyms | PTPK |
Function | Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. |
Cellular Location | Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein |
Tissue Location | High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma |
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Provided below are standard protocols that you may find useful for product applications.
Background
PTPkappa, a member of the receptor class 2B subfamily of protein-tyrosine phophatases, is involved in regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. It forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTP-kappa. This Type I membrane protein, localized at adherens junctions, is found at high levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. It contains 4 fibronectin type III domains, 1 immunoglobulin-like C2-type domain, 1 MAM domain, and 2 protein-tyrosine phosphatase domains.
References
Yang, Y., et al., Gene 186(1):77-82 (1997).Fuchs, M., et al., J. Biol. Chem. 271(28):16712-16719 (1996).
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