|Other Names||Receptor-type tyrosine-protein phosphatase kappa, Protein-tyrosine phosphatase kappa, R-PTP-kappa, PTPRK, PTPK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8417a was selected from the N-term region of human PTPkappa . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.|
|Cellular Location||Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein|
|Tissue Location||High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma|
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Provided below are standard protocols that you may find useful for product applications.
PTPkappa, a member of the receptor class 2B subfamily of protein-tyrosine phophatases, is involved in regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. It forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTP-kappa. This Type I membrane protein, localized at adherens junctions, is found at high levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. It contains 4 fibronectin type III domains, 1 immunoglobulin-like C2-type domain, 1 MAM domain, and 2 protein-tyrosine phosphatase domains.
Yang, Y., et al., Gene 186(1):77-82 (1997).Fuchs, M., et al., J. Biol. Chem. 271(28):16712-16719 (1996).
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