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PTP kappa Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q15262
Clone Names 1121008
Additional Information
Gene ID 5796
Other Names Receptor-type tyrosine-protein phosphatase kappa, Protein-tyrosine phosphatase kappa, R-PTP-kappa, PTPRK, PTPK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8417a was selected from the N-term region of human PTPkappa . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPRK
Synonyms PTPK
Function Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
Cellular Location Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein
Tissue Location High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma
Research Areas
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Background

PTPkappa, a member of the receptor class 2B subfamily of protein-tyrosine phophatases, is involved in regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. It forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTP-kappa. This Type I membrane protein, localized at adherens junctions, is found at high levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. It contains 4 fibronectin type III domains, 1 immunoglobulin-like C2-type domain, 1 MAM domain, and 2 protein-tyrosine phosphatase domains.

References

Yang, Y., et al., Gene 186(1):77-82 (1997).Fuchs, M., et al., J. Biol. Chem. 271(28):16712-16719 (1996).

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$ 80.00
Cat# BP8417a
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