|Other Names||Receptor-type tyrosine-protein phosphatase U, R-PTP-U, Pancreatic carcinoma phosphatase 2, PCP-2, Protein-tyrosine phosphatase J, PTP-J, hPTP-J, Protein-tyrosine phosphatase pi, PTP pi, Protein-tyrosine phosphatase receptor omicron, PTP-RO, Receptor-type protein-tyrosine phosphatase psi, R-PTP-psi, PTPRU, FMI, PCP2, PTPRO|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8418a was selected from the N-term region of human PTPlambda . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FMI, PCP2, PTPRO|
|Function||Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.|
|Cellular Location||Cell junction. Cell membrane; Single-pass type I membrane protein|
|Tissue Location||High levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach, and uterus; not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells|
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Provided below are standard protocols that you may find useful for product applications.
PTPlambda, a member of the receptor class 2B subfamily of protein-tyrosine phosophatases, is involved in regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. It forms complexes with beta-catenin and gamma-catenin/plakoglobin. This Type I membrane protein is found at high levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach, and uterus; no expression is observed in placenta and spleen. PTPlambda is up-regulated upon cell contact. The protein contains 4 fibronectin type III domains, 1 immunoglobulin-like C2-type domain, 1 MAM domain, and 2 protein-tyrosine phosphatase domains.
Wang, H., et al., Oncogene 12(12):2555-2562 (1996).
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