|Other Names||Receptor-type tyrosine-protein phosphatase S, R-PTP-S, Receptor-type tyrosine-protein phosphatase sigma, R-PTP-sigma, PTPRS|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8421a was selected from the C-term region of human PTP sigma. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Interacts with LAR-interacting protein LIP.1.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in all tissues tested except for placenta and liver|
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Provided below are standard protocols that you may find useful for product applications.
PTP sigma belongs to the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been also implicated in the molecular control of adult nerve repair.
Serra-Pages, C., et al., J. Biol. Chem. 273(25):15611-15620 (1998).Endo, N., et al., J. Bone Miner. Res. 11(4):535-543 (1996).Pulido, R., et al., Proc. Natl. Acad. Sci. U.S.A. 92(25):11686-11690 (1995).Adachi, M., et al., Cancer Res. 52(3):737-740 (1992).
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