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PTPN13 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q12923
Clone Names 1121005
Additional Information
Gene ID 5783
Other Names Tyrosine-protein phosphatase non-receptor type 13, Fas-associated protein-tyrosine phosphatase 1, FAP-1, PTP-BAS, Protein-tyrosine phosphatase 1E, PTP-E1, hPTPE1, Protein-tyrosine phosphatase PTPL1, PTPN13, PNP1, PTP1E, PTPL1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8423a was selected from the C-term region of human PTPN13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPN13
Synonyms PNP1, PTP1E, PTPL1
Function Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).
Cellular Location Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover
Tissue Location Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain
Research Areas
Citations (0)

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PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway.


Kachel, N., et al., J. Mol. Biol. 334(1):143-155 (2003).Ivanov, V.N., et al., Mol. Cell. Biol. 23(10):3623-3635 (2003).Bompard, G., et al., J. Biol. Chem. 277(49):47861-47869 (2002).Yoshida, S., et al., J. Hum. Genet. 47(11):614-619 (2002).Marin, L., et al., Transplant. Proc. 34(1):280-282 (2002).

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$ 80.00
Cat# BP8423a
(40 western blots)
Availability: In Stock
Bulk Size
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