|Other Names||Tyrosine-protein phosphatase non-receptor type 13, Fas-associated protein-tyrosine phosphatase 1, FAP-1, PTP-BAS, Protein-tyrosine phosphatase 1E, PTP-E1, hPTPE1, Protein-tyrosine phosphatase PTPL1, PTPN13, PNP1, PTP1E, PTPL1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8423a was selected from the C-term region of human PTPN13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||PNP1, PTP1E, PTPL1|
|Function||Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).|
|Cellular Location||Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover|
|Tissue Location||Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain|
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Provided below are standard protocols that you may find useful for product applications.
PTPN13 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway.
Kachel, N., et al., J. Mol. Biol. 334(1):143-155 (2003).Ivanov, V.N., et al., Mol. Cell. Biol. 23(10):3623-3635 (2003).Bompard, G., et al., J. Biol. Chem. 277(49):47861-47869 (2002).Yoshida, S., et al., J. Hum. Genet. 47(11):614-619 (2002).Marin, L., et al., Transplant. Proc. 34(1):280-282 (2002).
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