|Other Names||Tyrosine-protein phosphatase non-receptor type 21, Protein-tyrosine phosphatase D1, PTPN21, PTPD1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8424a was selected from the Center region of human PTPD1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
PTPD1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
Jui, H.Y., et al., J. Biol. Chem. 275(52):41124-41132 (2000).Tokuchi, H., et al., Int J Urol 6(11):572-577 (1999).Higashitsuji, H., et al., Oncogene 10(2):407-414 (1995).Moller, N.P., et al., Proc. Natl. Acad. Sci. U.S.A. 91(16):7477-7481 (1994).
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