|Other Names||Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8427a was selected from the N-term region of human PTPIA2beta . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in development of nervous system and pancreatic endocrine cells.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein|
|Tissue Location||Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord|
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Provided below are standard protocols that you may find useful for product applications.
PTPIA2beta is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.
Schmidli, R.S., et al., Autoimmunity 28(1):15-23 (1998).Li, Q., et al., Proc. Assoc. Am. Physicians 109(4):429-439 (1997).Cui, L., et al., J. Biol. Chem. 271(40):24817-24823 (1996).Kawasaki, E., et al., Biochem. Biophys. Res. Commun. 227(2):440-447 (1996).Smith, P.D., et al., Biochem. Biophys. Res. Commun. 229(2):402-411 (1996).
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