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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PTPIA2 Antibody (N-term) Blocking Peptide   

PTPIA2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q16849
Clone Names 2011601
Peptide ID 2011601
Additional Information
Gene ID 5798
Other Names Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8428a was selected from the N-term region of human PTPIA2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ICA3, ICA512
Function Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.
Cellular Location Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules
Tissue Location Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary
Research Areas
Citations (0)

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PTPIA2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.


Miao, D., et al., J. Autoimmun. 18(2):191-196 (2002).Cui, L., et al., J. Biol. Chem. 271(40):24817-24823 (1996).Lan, M.S., et al., DNA Cell Biol. 13(5):505-514 (1994).Rabin, D.U., et al., J. Immunol. 152(6):3183-3188 (1994).Mikulecky, M., et al., Biomed. Pharmacother. 55 Suppl 1, 106S-109S (2001).

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$ 80.00
Cat# BP8428a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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