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DUSP5 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q16690
Clone Names 4020922
Peptide ID 4020922
Additional Information
Gene ID 1847
Other Names Dual specificity protein phosphatase 5, Dual specificity protein phosphatase hVH3, DUSP5, VH3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8448a was selected from the N-term region of human DUSP5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP5
Synonyms VH3
Function Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1.
Cellular Location Nucleus.
Research Areas
Citations (0)

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DUSP5 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP5 inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.


Mandl, M., et al., Mol. Cell. Biol. 25(5):1830-1845 (2005).Ueda, K., et al., Oncogene 22(36):5586-5591 (2003).Kwak, S.P., et al., J. Biol. Chem. 270(3):1156-1160 (1995).Ishibashi, T., et al., J. Biol. Chem. 269(47):29897-29902 (1994).Martell, K.J., et al., Genomics 22(2):462-464 (1994).

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$ 80.00
Cat# BP8448a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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