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DUSP6 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q16828
Other Accession NP_001937
Clone Names 4020924
Peptide ID 4020924
Additional Information
Gene ID 1848
Other Names Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, DUSP6, MKP3, PYST1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8449a was selected from the Center region of human DUSP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP6
Synonyms MKP3, PYST1
Function Inactivates MAP kinases. Has a specificity for the ERK family.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.


Mod. Pathol. 18 (8), 1034-1042 (2005)J. Hum. Genet. 50 (4), 159-167 (2005)J. Biol. Chem. 279 (40), 41882-41891 (2004)Biochemistry 42 (51), 15197-15207 (2003)J. Biol. Chem. 271 (8), 4319-4326 (1996)

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$ 80.00
Cat# BP8449a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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