|Other Names||Dual specificity protein phosphatase 8, Dual specificity protein phosphatase hVH-5, DUSP8, C11orf81, VH5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8451b was selected from the C-term region of human DUSP8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Abundant in brain, heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin.
Berger, I.R., et al., Cancer Genet. Cytogenet. 159(2):155-159 (2005).Hink, R.L., et al., Genomics 8(3):305-312 (2003).Nesbit, M.A., et al., Genomics 42(2):284-294 (1997).Martell, K.J., et al., J. Neurochem. 65(4):1823-1833 (1995).
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