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DUSP12 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UNI6
Clone Names 4021104
Additional Information
Gene ID 11266
Other Names Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUSP12
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8454b was selected from the C-term region of human DUSP12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP12
Cellular Location Nucleus.
Tissue Location Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung
Research Areas
Citations (0)

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DUSP12 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP12 is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.


Muda, M., et al., J. Biol. Chem. 274(34):23991-23995 (1999).Groom, L.A., et al., EMBO J. 15(14):3621-3632 (1996).

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$ 80.00
Cat# BP8454b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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