|Other Names||Dual specificity protein phosphatase 16, Mitogen-activated protein kinase phosphatase 7, MAP kinase phosphatase 7, MKP-7, DUSP16, KIAA1700, MKP7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8458a was selected from the N-term region of human DUSP16. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasmic vesicle. Note=After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles|
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Provided below are standard protocols that you may find useful for product applications.
DUSP16 is involved in the inactivation of MAP kinases. The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis. For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs. MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.
Katagiri, C., et al., J. Biol. Chem. 280(15):14716-14722 (2005).Hoornaert, I., et al., Oncogene 22(49):7728-7736 (2003).Masuda, K., et al., J. Biol. Chem. 278(34):32448-32456 (2003).Willoughby, E.A., et al., J. Biol. Chem. 278(12):10731-10736 (2003).Masuda, K., et al., J. Biol. Chem. 276(42):39002-39011 (2001).
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