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PPM1F Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P49593
Clone Names 4021301
Peptide ID 4021301
Additional Information
Gene ID 9647
Other Names Protein phosphatase 1F, Ca(2+)/calmodulin-dependent protein kinase phosphatase, CaM-kinase phosphatase, CaMKPase, Partner of PIX 2, Protein fem-2 homolog, hFem-2, PPM1F, KIAA0015, POPX2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8459b was selected from the C-term region of human PPM1F. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPM1F
Synonyms KIAA0015, POPX2
Function Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
Research Areas
Citations (0)

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PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis.


Harvey, B.P., et al., J. Biol. Chem. 279(23):24889-24898 (2004).Izmailova, E., et al., Nat. Med. 9(2):191-197 (2003).Koh, C.G., et al., Curr. Biol. 12(4):317-321 (2002).Tan, K.M., et al., J. Biol. Chem. 276(47):44193-44202 (2001).

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$ 80.00
Cat# BP8459b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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