|Other Names||Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, Nuclear LIM interactor-interacting factor 2, NLI-interacting factor 2, Protein OS-4, Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, SCP2, CTDSP2, NIF2, OS4, SCP2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8460a was selected from the N-term region of human CTDSP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||NIF2, OS4, SCP2|
|Function||Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.|
|Tissue Location||Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver|
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Provided below are standard protocols that you may find useful for product applications.
CTDSP2 is one of several small CTD phosphatases (SCP). It has been proposed that SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes. In addition, expression of phosphatase CTDSP2 mRNA isenhanced in several cancer cell lines with amplification of the CTDSP2 and CDK4 genes, and CTDSP2 coamplifies with CDK4 in some primary sarcomas. CTDSP2 may contribute to the development of a subset of sarcomas.
Yeo, M., et al., J. Biol. Chem. 278(28):26078-26085 (2003).Su, Y.A., et al., Oncogene 15(11):1289-1294 (1997).Beutler, E., et al., Blood Cells Mol. Dis. 21(3):207-216 (1995).Su, Y.A., et al., Proc. Natl. Acad. Sci. U.S.A. 91(19):9121-9125 (1994).Su, Y.A., et al., Oncogene 15, 1290-1294 (1997) (): ().
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