|Other Names||Serine/threonine-protein phosphatase with EF-hands 1, PPEF-1, Protein phosphatase with EF calcium-binding domain, PPEF, Serine/threonine-protein phosphatase 7, PP7, PPEF1, PPEF, PPP7C|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8474a was selected from the N-term region of human PPEF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in the recovery or adaptation response of photoreceptors. May have a role in development.|
|Tissue Location||Detected in retina and retinal derived Y-79 retinoblastoma cells. Also found in fetal brain|
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Provided below are standard protocols that you may find useful for product applications.
PPEF1 is a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. The protein shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) protein.
Kutuzov, M.A., et al., Biochem. Biophys. Res. Commun. 293(3):1047-1052 (2002).Ramulu, P., et al., Mol. Cell. Biol. 21(24):8605-8614 (2001).Herzig, S., et al., Physiol. Rev. 80(1):173-210 (2000).Huang, X., et al., J. Biol. Chem. 273(3):1462-1468 (1998).Sherman, P.M., et al., Proc. Natl. Acad. Sci. U.S.A. 94(21):11639-11644 (1997).
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