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PPP4C Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P60510
Clone Names 4021332
Peptide ID 4021332
Additional Information
Gene ID 5531
Other Names Serine/threonine-protein phosphatase 4 catalytic subunit, PP4C, Pp4, Protein phosphatase X, PP-X, PPP4C, PPP4, PPX
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8475a was selected from the N-term region of human PPP4C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP4C
Synonyms PPP4, PPX
Function Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Cellular Location Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Research Areas
Citations (0)

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PPP4C belongs to the PPP phosphatase family, PP-X subfamily, and may participate in microtubule organization. Both overexpression and RNA interference experiments indicate that HDAC3 activity is inversely proportional to the cellular abundance of PPP4C. The PPP4C gene maps to chromosome 16p12-p11. Several translocations associated with acute leukemias have been mapped to this region of chromosome 16p.


Zhou, G., et al., J. Biol. Chem. 279(47):49551-49561 (2004).Mihindukulasuriya, K.A., et al., J. Biol. Chem. 279(45):46588-46594 (2004).Yeh, P.Y., et al., J. Biol. Chem. 279(25):26143-26148 (2004).Kloeker, S., et al., J. Biol. Chem. 274(9):5339-5347 (1999).Chen, J., et al., Biochem. Biophys. Res. Commun. 247(3):827-832 (1998).

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$ 80.00
Cat# BP8475a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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