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PP5 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P53041
Other Accession NP_006238
Clone Names 4021603
Peptide ID 4021603
Additional Information
Gene ID 5536
Other Names Serine/threonine-protein phosphatase 5, PP5, Protein phosphatase T, PP-T, PPT, PPP5C, PPP5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8476b was selected from the C-term region of human PPP5C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP5C
Synonyms PPP5
Function Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.
Cellular Location Nucleus. Cytoplasm. Membrane. Note=Predominantly nuclear. But also present in the cytoplasm
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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PPP5C belongs to the PPP phosphatase family, PP-T subfamily, and may play a role in the regulation of RNA biogenesis and/or mitosis. In vitro,PPP5C dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.


Yang, J., et al., EMBO J. 24(1):1-10 (2005).Zhou, G., et al., J. Biol. Chem. 279(45):46595-46605 (2004).Huang, S., et al., J. Biol. Chem. 279(35):36490-36496 (2004).Swingle, M.R., et al., J. Biol. Chem. 279(32):33992-33999 (2004).Wechsler, T., et al., Proc. Natl. Acad. Sci. U.S.A. 101(5):1247-1252 (2004).

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$ 80.00
Cat# BP8476b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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