|Other Names||Dual specificity protein phosphatase 22, JNK-stimulatory phosphatase-1, JSP-1, Low molecular weight dual specificity phosphatase 2, LMW-DSP2, Mitogen-activated protein kinase phosphatase x, MAP kinase phosphatase x, MKP-x, DUSP22, JSP1, LMWDSP2, MKPX|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8482a was selected from the N-term region of human DUSP22. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||JSP1, LMWDSP2, MKPX|
|Function||Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
DUSP22 is member of the dual-specificity phosphatase (DSP) family, which catalyzes dephosphorylation of phosphotyrosine and phosphothreonine residues.
Sekine,Y., Oncogene 26 (41), 6038-6049 (2007)Chen,A.J., J. Biol. Chem. 277 (39), 36592-36601 (2002)
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