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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PLA2G4A Antibody (Center) Blocking Peptide   

PLA2G4A Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P47712
Clone Names 90625177
Peptide ID 90625177
Additional Information
Gene ID 5321
Other Names Cytosolic phospholipase A2, cPLA2, Phospholipase A2 group IVA, Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Lysophospholipase, PLA2G4A, CPLA2, PLA2G4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8510c was selected from the Center region of human PLA2G4A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLA2G4A
Synonyms CPLA2, PLA2G4
Function Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Cellular Location Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion
Tissue Location Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium
Research Areas
Citations (0)

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PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.


Sharp,J.D.,, J. Biol. Chem. 266 (23), 14850-14853 (1991)Clark,J.D.,, Cell 65 (6), 1043-1051 (1991)

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$ 80.00
Cat# BP8510c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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