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TIP120A Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q86VP6
Clone Names 80924250
Peptide ID 80924250
Additional Information
Gene ID 55832
Other Names Cullin-associated NEDD8-dissociated protein 1, Cullin-associated and neddylation-dissociated protein 1, TBP-interacting protein of 120 kDa A, TBP-interacting protein 120A, p120 CAND1, CAND1, KIAA0829, TIP120, TIP120A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8519c was selected from the Center region of human TIP120A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAND1
Synonyms KIAA0829, TIP120, TIP120A
Function Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic
Research Areas
Citations (0)

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TIP120A enhances transcription from various types of promoters. It is regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. It prevents neddylation of CUL1 by physically blocking access to the neddylation site and disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins.


Feng,S.,, Plant Cell 16 (7), 1870-1882 (2004)Zheng,J.,, Mol. Cell 10 (6), 1519-1526 (2002)

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$ 80.00
Cat# BP8519c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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