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MyD88 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q99836
Clone Names 90415003
Peptide ID 90415003
Additional Information
Gene ID 4615
Other Names Myeloid differentiation primary response protein MyD88, MYD88
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8521c was selected from the Center region of human MyD88. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYD88
Function Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Cellular Location Cytoplasm
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Background

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. It acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response and increases IL-8 transcription. It may be involved in myeloid differentiation.

References

Bannon,C., et.al., Biochem. J. 423 (1), 119-128 (2009)Burns,K., et.al., J. Biol. Chem. 273 (20), 12203-12209 (1998)

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$ 80.00
Cat# BP8521c
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